Principaux biomarqueurs pour le diagnostic de la maladie d’Alzheimer en 2020

Dimension de la maladie

IRM

Imagerie nucléaire

Biomarqueurs du LCS

Biomarqueurs sanguins

Accumulation de peptide amyloïde
TEP amyloïde**
➘ Peptide Aβ 1-42*
Aβ 1-40 / Aβ 1-42**
Accumulation de protéine tau phosphorylée
TEP tau**
➚ Protéine tau phosphorylée*
Neurodégénérescence
Atrophie hippocampique*
➚ Protéine tau totale*
➚ Neurofilaments**
➚ Protéine tau totale**
Tableau. IRM : imagerie par résonance magnétique ; LCS : liquide cérébrospinal ; TEP : tomographie par émission de positons. Légende : * : pratique clinique, ** : recherche.

<table><thead/><tbody><tr AutoGrow="true" ClipContentToTextCell="false" MinimumHeight="17.007874015748033" Name="0" Self="u25b50i25b65Row0" SingleRowHeight="17.007874015748033" TextBottomInset="4" TextLeftInset="4" TextRightInset="4" TextTopInset="4.818897637795276"><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Black" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="268" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0" BottomInset="4" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/Black" FillTint="-1" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Black" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokeOverprint="false" LeftEdgeStrokePriority="265" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0" LeftInset="4" Name="0:0" RightEdgeStrokeColor="Swatch/None" RightEdgeStrokePriority="271" RightEdgeStrokeTint="100" RightEdgeStrokeWeight="0" RightInset="4" RowSpan="1" Self="u25b50i25b65i0" TextBottomInset="4" TextLeftInset="4" TextRightInset="4" TextTopInset="4.818897637795276" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="266" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0" TopInset="4.818897637795276" WritingDirection="true" colspan="5"><tableau_titre>Principaux biomarqueurs pour le diagnostic de la maladie d’Alzheimer en 2020</tableau_titre></td></tr><tr AutoGrow="true" ClipContentToTextCell="false" MinimumHeight="17.007874015748033" Name="1" Self="u25b50i25b65Row1" SingleRowHeight="24.50787401574803" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017"><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="205" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FirstBaselineOffset="AscentOffset" LeftEdgeStrokePriority="58" LeftEdgeStrokeWeight="0" LeftInset="4" Name="0:1" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i1" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="268" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_tetiere>Dimension de la maladie</tableau_tetiere></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="205" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="1:1" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i5" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="268" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_tetiere>IRM</tableau_tetiere></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="205" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="2:1" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65if" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="268" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_tetiere>Imagerie nucléaire</tableau_tetiere></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="205" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="3:1" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i12" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="268" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_tetiere>Biomarqueurs du LCS</tableau_tetiere></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="205" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="4:1" RightEdgeStrokeColor="Swatch/None" RightEdgeStrokePriority="271" RightEdgeStrokeTint="100" RightEdgeStrokeWeight="0" RightInset="4" RowSpan="1" Self="u25b50i25b65ib" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="268" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_tetiere>Biomarqueurs sanguins</tableau_tetiere></td></tr><tr AutoGrow="true" ClipContentToTextCell="false" MinimumHeight="17.007874015748033" Name="2" Self="u25b50i25b65Row2" SingleRowHeight="35.00787401574803" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017"><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="137" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0" LeftInset="4" Name="0:2" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i6" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="205" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>Accumulation de peptide amyloïde</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="1:2" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i11" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="205" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>–</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=0 M=85 J=90 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="2:2" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i10" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="205" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>TEP amyloïde**</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="3:2" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65ie" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="205" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>➘ Peptide Aβ 1-42*</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=0 M=85 J=90 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="4:2" RightEdgeStrokeColor="Swatch/None" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="271" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0" RightInset="4" RowSpan="1" Self="u25b50i25b65i15" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="205" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>Aβ 1-40 / Aβ 1-42**</tableau_texte></td></tr><tr AutoGrow="true" ClipContentToTextCell="false" MinimumHeight="17.007874015748033" Name="3" Self="u25b50i25b65Row3" SingleRowHeight="35.10553026574803" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017"><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="137" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0" LeftInset="4" Name="0:3" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i19" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>Accumulation de protéine tau phosphorylée</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="1:3" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i1a" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>–</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=0 M=85 J=90 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="2:3" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i1b" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>TEP tau**</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="3:3" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i1c" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>➚ Protéine tau phosphorylée*</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Paper" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokePriority="211" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="0.5" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="4:3" RightEdgeStrokeColor="Swatch/None" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="271" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0" RightInset="4" RowSpan="1" Self="u25b50i25b65i1d" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>–</tableau_texte></td></tr><tr AutoGrow="true" ClipContentToTextCell="false" MinimumHeight="17.007874015748033" Name="4" Self="u25b50i25b65Row4" SingleRowHeight="37.94017593503937" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017"><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Black" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="269" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="2" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="137" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0" LeftInset="4" Name="0:4" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i2" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>Neurodégénérescence</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Black" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="269" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="2" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="1:4" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65i16" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>Atrophie hippocampique*</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Black" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="269" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="2" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="15" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="2:4" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65ic" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>–</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Black" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="269" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="2" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=95 M=0 J=45 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="3:4" RightEdgeStrokeColor="Color/Paper" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="196" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0.5" RightInset="4" RowSpan="1" Self="u25b50i25b65ia" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>➚ Protéine tau totale*</tableau_texte></td><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeColor="Color/Black" BottomEdgeStrokeGapColor="Color/Paper" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="269" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="StrokeStyle/$ID/Solid" BottomEdgeStrokeWeight="2" BottomInset="8.503937007874017" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FillColor="Color/C=0 M=85 J=90 N=0" FillTint="50" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeColor="Color/Paper" LeftEdgeStrokeGapColor="Color/Paper" LeftEdgeStrokeGapTint="100" LeftEdgeStrokePriority="196" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="StrokeStyle/$ID/Solid" LeftEdgeStrokeWeight="0.5" LeftInset="4" Name="4:4" RightEdgeStrokeColor="Swatch/None" RightEdgeStrokeGapColor="Color/Paper" RightEdgeStrokeGapTint="100" RightEdgeStrokePriority="271" RightEdgeStrokeTint="100" RightEdgeStrokeType="StrokeStyle/$ID/Solid" RightEdgeStrokeWeight="0" RightInset="4" RowSpan="1" Self="u25b50i25b65i14" TextBottomInset="8.503937007874017" TextLeftInset="4" TextRightInset="4" TextTopInset="8.503937007874017" TopEdgeStrokeColor="Color/Paper" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokePriority="211" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="0.5" TopInset="8.503937007874017" WritingDirection="true" colspan="1"><tableau_texte>➚ Neurofilaments**</tableau_texte><tableau_texte>➚ Protéine tau totale**</tableau_texte></td></tr><tr AutoGrow="true" ClipContentToTextCell="false" MinimumHeight="22.67716535433071" Name="5" Self="u25b50i25b65Row5" SingleRowHeight="22.67716535433071" TextBottomInset="0" TextLeftInset="0" TextRightInset="0" TextTopInset="3.999685039370079"><td AppliedCellStyle="CellStyle/$ID/[None]" AppliedCellStylePriority="0" BottomEdgeStrokeGapOverprint="false" BottomEdgeStrokeGapTint="100" BottomEdgeStrokeOverprint="false" BottomEdgeStrokePriority="57" BottomEdgeStrokeTint="100" BottomEdgeStrokeType="n" BottomEdgeStrokeWeight="0" BottomInset="0" CellType="TextTypeCell" ClipContentToCell="false" ClipContentToTextCell="false" FirstBaselineOffset="AscentOffset" LeftEdgeStrokeGapOverprint="false" LeftEdgeStrokeGapTint="100" LeftEdgeStrokeOverprint="false" LeftEdgeStrokePriority="57" LeftEdgeStrokeTint="100" LeftEdgeStrokeType="n" LeftEdgeStrokeWeight="0" LeftInset="0" Name="0:5" RightEdgeStrokeColor="Swatch/None" RightEdgeStrokePriority="270" RightInset="0" RowSpan="1" Self="u25b50i25b65i7" TextBottomInset="0" TextLeftInset="0" TextRightInset="0" TextTopInset="3.999685039370079" TopEdgeStrokeColor="Color/Black" TopEdgeStrokeGapColor="Color/Paper" TopEdgeStrokeGapTint="100" TopEdgeStrokeOverprint="false" TopEdgeStrokePriority="269" TopEdgeStrokeTint="100" TopEdgeStrokeType="StrokeStyle/$ID/Solid" TopEdgeStrokeWeight="2" TopInset="3.999685039370079" WritingDirection="true" colspan="5"><tableau_legende>Tableau. IRM : imagerie par résonance magnétique ; LCS : liquide cérébrospinal ; TEP : tomographie par émission de positons. Légende : * : pratique clinique, ** : recherche.</tableau_legende></td></tr></tbody></table>

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